When domperidone was being used for babies (and now that cisapride is off the market, it is being used again), it was common for the babies to be on the medication for several months, even longer. Since the amount of domperidone that gets into the milk is very small indeed, from the baby’s point of view, there should be no issue in the mother taking it to increase milk supply for several months. Our experience with this drug is that short-term side effects are very few and almost always very mild. Worldwide experience with domperidone over at least two decades suggests that long-term side effects also are rare. Some of the mothers in our clinic, breastfeeding adopted babies, have been on the medication for 18 months without any apparent side effects. As mentioned in the information sheet Domperidone, Getting Started, patients using domperidone for stomach disorders may be on it for many years. We hope you won’t need domperidone for very long, but if it’s necessary and helpful, stay on it.
It depends on the situation. In a situation where the mother had had a good milk supply, but it decreased for some reason (e.g. going on the birth control pill, see the information sheet Slow Weight Following Early Good Weight Gain), domperidone often works very rapidly to increase the milk supply. Often, within a day or two the mother is seeing a difference (and so does her baby). But this is not always so, and in many situations, it may take a week or more for the mother to start getting an effect. On occasion, we have had mothers only starting to get an increase in their milk supplies a month or more after starting to take it. Therefore, we generally recommended that the mother take the domperidone for at least six weeks in order to be sure whether it has worked or not.
It is our impression that domperidone works best after the first few weeks after the mother has given birth (usually after about four weeks). This has not been proved, but there are theoretical reasons why it may be so. For this reason, we have often waited to prescribe it until the baby is at least three weeks, mainly because we did not want the mother to become discouraged if she did not see any rapid increase in her milk supply. If you keep this in mind, taking domperidone before three or four weeks after the birth of the baby is worth a try because sometimes it does work very well early on.
Usually, we ask the mother take it for at least two weeks at a minimum and then re-evaluate the situation. There are several possibilities.
In the first situation (but not necessarily always in that situation), we may suggest the mother start weaning herself from the domperidone in this way:
It is possible, however, that after two weeks of taking domperidone, you are not where you want to be. In that case, you should continue using the domperidone. If you are still not where you want to be after two to six weeks of domperidone, it is time to think some more about the domperidone. If you are supplementing, and have managed to reduce the amount of supplement from 400 ml to 300 ml (14 ounces to 10 ounces), is it really worth taking a drug in order to do this? I would say yes, but this is up to you. If you feel it is, then continue with the domperidone, but try weaning the number of pills down to minimum number that maintain your milk supply, as above. If you do not feel it is worth it, try weaning down as above, and if you don’t see any change once you get to no pills a day, fine. However, if you do notice a real change in the milk supply as you lower the dose, maybe the domperidone is more effective than you had thought (remember, after several weeks, your baby is significantly heavier, and it may be that instead of needing 400 ml (14 ounces) without domperidone, the baby might actually need 20 ounces to maintain good weight gain, in which case the domperidone is actually doing something).
Remember: Before using domperidone, the breastfeeding should be fixed, and as quickly as possible. This means:
Although most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother’s milk supply to adjust without frustrating the baby or causing her discomfort.
It is very important to stop the domperidone slowly.
Newman-Goldfarb Protocols for Induced Lactation® © 2002-2010
Jack Newman, MD, FRCPC and Lenore Goldfarb, PhD, CCC, IBCLC, ALC
The information contained in this patient handout is a suggestion only, and is not a substitute for consultation with a health professional or lactation specialist. This handout is the property of the author(s) and the Goldfarb Breastfeeding Clinic. No part of this handout can be changed or modified without permission from the author and the Goldfarb Breastfeeding Clinic. This handout may be copied and distributed without further permission on the condition that it is not used in any context in which the International Code for the Marketing of Breastmilk Substitutes is violated. For more information, please contact the Goldfarb Breastfeeding Clinic, Herzl Family Practice Centre, SMBD Jewish General Hospital, Montreal, Quebec, Canada. © 2009
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